Minimal Change Nephrotic Syndrome Superimposed on Type 2 Diabetic Glomerulosclerosis

Diabetic nephropathy is one of the most important causes of endstage renal disease that requires renal replacement therapy and accounts for more than 40% of the new cases in Japan and Western countries [1]. In particular, the prevalence of type 2 diabetic nephropathy in end-stage renal failure has rapidly increased [2]. Patients with type 2 diabetes are also known to have non-diabetic glomerular diseases with a reported incidence of 25–35% [3]. Stoycheff et al. [4] reported that 44% of patients with type 2 diabetic nephropathy and proteinuria greater than 0.9 g/day had nephrotic-range heavy proteinuria. However, the exact prevalence of nephrotic syndrome in patients with macroalbuminuric diabetic nephropathy and non-diabetic glomerular disease associated with nephrotic syndrome in patients with type 2 diabetes mellitus remains uncertain.